Common genetic variants in prostate cancer risk prediction – Results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3)
Identifieur interne : 005434 ( Main/Exploration ); précédent : 005433; suivant : 005435Common genetic variants in prostate cancer risk prediction – Results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3)
Auteurs : Sara Lindström [États-Unis] ; Fredrick R. Schumacher [États-Unis] ; David Cox [France, Royaume-Uni] ; Ruth C. Travis [Royaume-Uni] ; Demetrius Albanes [États-Unis] ; Naomi E. Allen [Royaume-Uni] ; Gerald Andriole [États-Unis] ; Sonja I. Berndt [États-Unis] ; Heiner Boeing [Allemagne] ; H. Bas Bueno-De-Mesquita [Pays-Bas] ; E. David Crawford [États-Unis] ; W. Ryan Diver [États-Unis] ; J. Michael Ganziano [États-Unis] ; Graham G. Giles [Australie] ; Edward Giovannucci [États-Unis] ; Carlos A. Gonzalez [Espagne] ; Brian Henderson [États-Unis] ; David J. Hunter [États-Unis] ; Mattias Johansson [France, Suède] ; Laurence N. Kolonel [États-Unis] ; Jing Ma [États-Unis] ; Loic Le Marchand [États-Unis] ; Valeria Pala [Italie] ; Meir Stampfer [États-Unis] ; Daniel O. Stram [États-Unis] ; Michael J. Thun [États-Unis] ; Anne Tjonneland [Danemark] ; Dimitrios Trichopoulos [États-Unis, Grèce] ; Jarmo Virtamo [Finlande] ; Stephanie J. Weinstein [États-Unis] ; Walter C. Willett [États-Unis] ; Meredith Yeager [États-Unis] ; Richard B. Hayes [États-Unis] ; Gianluca Severi [Australie] ; Christopher A. Haiman [États-Unis] ; Stephen J. Chanock [États-Unis] ; Peter Kraft [États-Unis]Source :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [ 1055-9965 ] ; 2012.
Abstract
One of the goals of personalized medicine is to generate individual risk profiles that could identify individuals in the population that exhibit high risk. The discovery of more than two-dozen independent SNP markers in prostate cancer has raised the possibility for such risk stratification. In this study, we evaluated the discriminative and predictive ability for prostate cancer risk models incorporating 25 common prostate cancer genetic markers, family history of prostate cancer and age.
We fit a series of risk models and estimated their performance in 7,509 prostate cancer cases and 7,652 controls within the NCI Breast and Prostate Cancer Cohort Consortium (BPC3). We also calculated absolute risks based on SEER incidence data.
The best risk model (C-statistic=0.642) included individual genetic markers and family history of prostate cancer. We observed a decreasing trend in discriminative ability with advancing age (
Our results indicate that incorporating genetic information and family history in prostate cancer risk models can be particularly useful for identifying younger men that might benefit from PSA screening.
Although adding genetic risk markers improves model performance, the clinical utility of these genetic risk models is limited.
Url:
DOI: 10.1158/1055-9965.EPI-11-1038
PubMed: 22237985
PubMed Central: 3318963
Affiliations:
- Allemagne, Australie, Danemark, Espagne, Finlande, France, Grèce, Italie, Pays-Bas, Royaume-Uni, Suède, États-Unis
- Angleterre, Auvergne-Rhône-Alpes, Californie, Catalogne, Colorado, Grand Londres, Géorgie (États-Unis), Hawaï, Hovedstaden, Lombardie, Maryland, Massachusetts, Missouri (État), Oxfordshire, Rhône-Alpes, Utrecht (province), Victoria (État), État de New York
- Barcelone, Copenhague, Londres, Los Angeles, Lyon, Melbourne, Milan, Oxford, Saint-Louis (Missouri), Utrecht
- Université d'Oxford, Université de Californie du Sud, Université de Melbourne, École de médecine (Université Washington de Saint-Louis)
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Allen</name><affiliation wicri:level="4"><nlm:aff id="A6">Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Andriole, Gerald" sort="Andriole, Gerald" uniqKey="Andriole G" first="Gerald" last="Andriole">Gerald Andriole</name><affiliation wicri:level="4"><nlm:aff id="A8">Division of Urologic Surgery, Washington University School of Medicine, St Louis, MO, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Urologic Surgery, Washington University School of Medicine, St Louis, MO</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. 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Bas" last="Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name><affiliation wicri:level="1"><nlm:aff id="A10">National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Institute for Public Health and the Environment (RIVM), Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A11">Department of Gastroenterology and Hepatology, University Medical Centre Utrecht (UMCU), Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Gastroenterology and Hepatology, University Medical Centre Utrecht (UMCU), Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Crawford, E David" sort="Crawford, E David" uniqKey="Crawford E" first="E. David" last="Crawford">E. David Crawford</name><affiliation wicri:level="2"><nlm:aff id="A12">Urologic Oncology, University of Colorado Health Sciences Center, Denver, CO, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Urologic Oncology, University of Colorado Health Sciences Center, Denver, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W. Ryan" last="Diver">W. 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Michael Ganziano</name><affiliation wicri:level="2"><nlm:aff id="A14">Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC) and Geriatric Research, Education, and Clinical Center (GRECC), Boston Veterans Affairs Healthcare System, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC) and Geriatric Research, Education, and Clinical Center (GRECC), Boston Veterans Affairs Healthcare System, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A15">Division of Aging, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Aging, Department of Medicine, Brigham and Women’s Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation wicri:level="4"><nlm:aff id="A16">Cancer Epidemiology Centre, Cancer Council Victoria and the Centre for Molecular, Genetic, Environmental, and Analytic Epidemiology, University of Melbourne, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria and the Centre for Molecular, Genetic, Environmental, and Analytic Epidemiology, University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A17">Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Epidemiology and Preventive Medicine, Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Giovannucci, Edward" sort="Giovannucci, Edward" uniqKey="Giovannucci E" first="Edward" last="Giovannucci">Edward Giovannucci</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A18">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A20">Department of Medicine, Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Gonzalez, Carlos A" sort="Gonzalez, Carlos A" uniqKey="Gonzalez C" first="Carlos A." last="Gonzalez">Carlos A. Gonzalez</name><affiliation wicri:level="3"><nlm:aff id="A19">Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (IDIBELL, RETICC -RD06/0020), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (IDIBELL, RETICC -RD06/0020), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Henderson, Brian" sort="Henderson, Brian" uniqKey="Henderson B" first="Brian" last="Henderson">Brian Henderson</name><affiliation wicri:level="4"><nlm:aff id="A3">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation wicri:level="2"><nlm:aff id="A1">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A20">Department of Medicine, Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation wicri:level="3"><nlm:aff id="A21">International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A22">Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University</wicri:regionArea><wicri:noRegion>Umeå University</wicri:noRegion></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name><affiliation wicri:level="2"><nlm:aff id="A23">Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI</wicri:regionArea><placeName><region type="state">Hawaï</region></placeName></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation wicri:level="2"><nlm:aff id="A20">Department of Medicine, Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="2"><nlm:aff id="A23">Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI</wicri:regionArea><placeName><region type="state">Hawaï</region></placeName></affiliation></author><author><name sortKey="Pala, Valeria" sort="Pala, Valeria" uniqKey="Pala V" first="Valeria" last="Pala">Valeria Pala</name><affiliation wicri:level="3"><nlm:aff id="A24">Department of Predictive Medicine, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Predictive Medicine, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Stampfer, Meir" sort="Stampfer, Meir" uniqKey="Stampfer M" first="Meir" last="Stampfer">Meir Stampfer</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A18">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A20">Department of Medicine, Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O." last="Stram">Daniel O. Stram</name><affiliation wicri:level="4"><nlm:aff id="A3">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Thun, Michael J" sort="Thun, Michael J" uniqKey="Thun M" first="Michael J." last="Thun">Michael J. Thun</name><affiliation wicri:level="2"><nlm:aff id="A13">Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Tjonneland, Anne" sort="Tjonneland, Anne" uniqKey="Tjonneland A" first="Anne" last="Tjonneland">Anne Tjonneland</name><affiliation wicri:level="3"><nlm:aff id="A25">Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">Bureau of Epidemiologic Research, Academy of Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Bureau of Epidemiologic Research, Academy of Athens</wicri:regionArea><wicri:noRegion>Academy of Athens</wicri:noRegion></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation wicri:level="1"><nlm:aff id="A27">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Weinstein, Stephanie J" sort="Weinstein, Stephanie J" uniqKey="Weinstein S" first="Stephanie J." last="Weinstein">Stephanie J. Weinstein</name><affiliation wicri:level="2"><nlm:aff id="A7">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Willett, Walter C" sort="Willett, Walter C" uniqKey="Willett W" first="Walter C." last="Willett">Walter C. Willett</name><affiliation wicri:level="2"><nlm:aff id="A18">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Yeager, Meredith" sort="Yeager, Meredith" uniqKey="Yeager M" first="Meredith" last="Yeager">Meredith Yeager</name><affiliation wicri:level="2"><nlm:aff id="A7">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B." last="Hayes">Richard B. Hayes</name><affiliation wicri:level="2"><nlm:aff id="A28">Division of Epidemiology, NYU Langone Medical Center, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, NYU Langone Medical Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation wicri:level="4"><nlm:aff id="A16">Cancer Epidemiology Centre, Cancer Council Victoria and the Centre for Molecular, Genetic, Environmental, and Analytic Epidemiology, University of Melbourne, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria and the Centre for Molecular, Genetic, Environmental, and Analytic Epidemiology, University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="4"><nlm:aff id="A3">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="2"><nlm:aff id="A7">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="2"><nlm:aff id="A1">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A29">Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22237985</idno><idno type="pmc">3318963</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318963</idno><idno type="RBID">PMC:3318963</idno><idno type="doi">10.1158/1055-9965.EPI-11-1038</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002086</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002086</idno><idno type="wicri:Area/Pmc/Curation">001F40</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001F40</idno><idno type="wicri:Area/Pmc/Checkpoint">002013</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002013</idno><idno type="wicri:Area/Ncbi/Merge">000C74</idno><idno type="wicri:Area/Ncbi/Curation">000C74</idno><idno type="wicri:Area/Ncbi/Checkpoint">000C74</idno><idno type="wicri:doubleKey">1055-9965:2012:Lindstrom S:common:genetic:variants</idno><idno type="wicri:Area/Main/Merge">005690</idno><idno type="wicri:Area/Main/Curation">005434</idno><idno type="wicri:Area/Main/Exploration">005434</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Common genetic variants in prostate cancer risk prediction – Results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3)</title><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name><affiliation wicri:level="2"><nlm:aff id="A1">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><affiliation wicri:level="4"><nlm:aff id="A3">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Cox, David" sort="Cox, David" uniqKey="Cox D" first="David" last="Cox">David Cox</name><affiliation wicri:level="3"><nlm:aff id="A4">Cancer Research Center of Lyon, Centre Léon Bérard, INSERM U1052, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Cancer Research Center of Lyon, Centre Léon Bérard, INSERM U1052, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A5">Department of Medicine and Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medicine and Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation wicri:level="4"><nlm:aff id="A6">Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation wicri:level="2"><nlm:aff id="A7">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Allen, Naomi E" sort="Allen, Naomi E" uniqKey="Allen N" first="Naomi E." last="Allen">Naomi E. Allen</name><affiliation wicri:level="4"><nlm:aff id="A6">Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Andriole, Gerald" sort="Andriole, Gerald" uniqKey="Andriole G" first="Gerald" last="Andriole">Gerald Andriole</name><affiliation wicri:level="4"><nlm:aff id="A8">Division of Urologic Surgery, Washington University School of Medicine, St Louis, MO, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Urologic Surgery, Washington University School of Medicine, St Louis, MO</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="2"><nlm:aff id="A7">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Epidemiology, Deutsches Institut für Ernährungsforschung, Potsdam-Rehbrücke, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Epidemiology, Deutsches Institut für Ernährungsforschung, Potsdam-Rehbrücke</wicri:regionArea><wicri:noRegion>Potsdam-Rehbrücke</wicri:noRegion><wicri:noRegion>Potsdam-Rehbrücke</wicri:noRegion><wicri:noRegion>Potsdam-Rehbrücke</wicri:noRegion></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H. Bas" last="Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name><affiliation wicri:level="1"><nlm:aff id="A10">National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Institute for Public Health and the Environment (RIVM), Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A11">Department of Gastroenterology and Hepatology, University Medical Centre Utrecht (UMCU), Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Gastroenterology and Hepatology, University Medical Centre Utrecht (UMCU), Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Crawford, E David" sort="Crawford, E David" uniqKey="Crawford E" first="E. David" last="Crawford">E. David Crawford</name><affiliation wicri:level="2"><nlm:aff id="A12">Urologic Oncology, University of Colorado Health Sciences Center, Denver, CO, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Urologic Oncology, University of Colorado Health Sciences Center, Denver, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W. Ryan" last="Diver">W. Ryan Diver</name><affiliation wicri:level="2"><nlm:aff id="A13">Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Ganziano, J Michael" sort="Ganziano, J Michael" uniqKey="Ganziano J" first="J. Michael" last="Ganziano">J. Michael Ganziano</name><affiliation wicri:level="2"><nlm:aff id="A14">Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC) and Geriatric Research, Education, and Clinical Center (GRECC), Boston Veterans Affairs Healthcare System, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC) and Geriatric Research, Education, and Clinical Center (GRECC), Boston Veterans Affairs Healthcare System, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A15">Division of Aging, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Aging, Department of Medicine, Brigham and Women’s Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation wicri:level="4"><nlm:aff id="A16">Cancer Epidemiology Centre, Cancer Council Victoria and the Centre for Molecular, Genetic, Environmental, and Analytic Epidemiology, University of Melbourne, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria and the Centre for Molecular, Genetic, Environmental, and Analytic Epidemiology, University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A17">Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Epidemiology and Preventive Medicine, Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Giovannucci, Edward" sort="Giovannucci, Edward" uniqKey="Giovannucci E" first="Edward" last="Giovannucci">Edward Giovannucci</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A18">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A20">Department of Medicine, Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Gonzalez, Carlos A" sort="Gonzalez, Carlos A" uniqKey="Gonzalez C" first="Carlos A." last="Gonzalez">Carlos A. Gonzalez</name><affiliation wicri:level="3"><nlm:aff id="A19">Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (IDIBELL, RETICC -RD06/0020), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (IDIBELL, RETICC -RD06/0020), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Henderson, Brian" sort="Henderson, Brian" uniqKey="Henderson B" first="Brian" last="Henderson">Brian Henderson</name><affiliation wicri:level="4"><nlm:aff id="A3">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation wicri:level="2"><nlm:aff id="A1">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A20">Department of Medicine, Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation wicri:level="3"><nlm:aff id="A21">International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A22">Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University</wicri:regionArea><wicri:noRegion>Umeå University</wicri:noRegion></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name><affiliation wicri:level="2"><nlm:aff id="A23">Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI</wicri:regionArea><placeName><region type="state">Hawaï</region></placeName></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation wicri:level="2"><nlm:aff id="A20">Department of Medicine, Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="2"><nlm:aff id="A23">Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI</wicri:regionArea><placeName><region type="state">Hawaï</region></placeName></affiliation></author><author><name sortKey="Pala, Valeria" sort="Pala, Valeria" uniqKey="Pala V" first="Valeria" last="Pala">Valeria Pala</name><affiliation wicri:level="3"><nlm:aff id="A24">Department of Predictive Medicine, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Predictive Medicine, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Stampfer, Meir" sort="Stampfer, Meir" uniqKey="Stampfer M" first="Meir" last="Stampfer">Meir Stampfer</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A18">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A20">Department of Medicine, Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O." last="Stram">Daniel O. Stram</name><affiliation wicri:level="4"><nlm:aff id="A3">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Thun, Michael J" sort="Thun, Michael J" uniqKey="Thun M" first="Michael J." last="Thun">Michael J. Thun</name><affiliation wicri:level="2"><nlm:aff id="A13">Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Tjonneland, Anne" sort="Tjonneland, Anne" uniqKey="Tjonneland A" first="Anne" last="Tjonneland">Anne Tjonneland</name><affiliation wicri:level="3"><nlm:aff id="A25">Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">Bureau of Epidemiologic Research, Academy of Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Bureau of Epidemiologic Research, Academy of Athens</wicri:regionArea><wicri:noRegion>Academy of Athens</wicri:noRegion></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation wicri:level="1"><nlm:aff id="A27">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Weinstein, Stephanie J" sort="Weinstein, Stephanie J" uniqKey="Weinstein S" first="Stephanie J." last="Weinstein">Stephanie J. Weinstein</name><affiliation wicri:level="2"><nlm:aff id="A7">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Willett, Walter C" sort="Willett, Walter C" uniqKey="Willett W" first="Walter C." last="Willett">Walter C. Willett</name><affiliation wicri:level="2"><nlm:aff id="A18">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Yeager, Meredith" sort="Yeager, Meredith" uniqKey="Yeager M" first="Meredith" last="Yeager">Meredith Yeager</name><affiliation wicri:level="2"><nlm:aff id="A7">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B." last="Hayes">Richard B. Hayes</name><affiliation wicri:level="2"><nlm:aff id="A28">Division of Epidemiology, NYU Langone Medical Center, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, NYU Langone Medical Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation wicri:level="4"><nlm:aff id="A16">Cancer Epidemiology Centre, Cancer Council Victoria and the Centre for Molecular, Genetic, Environmental, and Analytic Epidemiology, University of Melbourne, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria and the Centre for Molecular, Genetic, Environmental, and Analytic Epidemiology, University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="4"><nlm:aff id="A3">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="2"><nlm:aff id="A7">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="2"><nlm:aff id="A1">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A29">Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="ISSN">1055-9965</idno><idno type="eISSN">1538-7755</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">One of the goals of personalized medicine is to generate individual risk profiles that could identify individuals in the population that exhibit high risk. The discovery of more than two-dozen independent SNP markers in prostate cancer has raised the possibility for such risk stratification. In this study, we evaluated the discriminative and predictive ability for prostate cancer risk models incorporating 25 common prostate cancer genetic markers, family history of prostate cancer and age.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We fit a series of risk models and estimated their performance in 7,509 prostate cancer cases and 7,652 controls within the NCI Breast and Prostate Cancer Cohort Consortium (BPC3). We also calculated absolute risks based on SEER incidence data.</p></sec><sec id="S3"><title>Results</title><p id="P3">The best risk model (C-statistic=0.642) included individual genetic markers and family history of prostate cancer. We observed a decreasing trend in discriminative ability with advancing age (<italic>P</italic>=0.009), with highest accuracy in men younger than 60 years (C-statistic=0.679). The absolute ten-year risk for 50-year old men with a family history ranged from 1.6% (10<sup>th</sup> percentile of genetic risk) to 6.7% (90<sup>th</sup> percentile of genetic risk). For men without family history, the risk ranged from 0.8% (10<sup>th</sup> percentile) to 3.4% (90<sup>th</sup> percentile).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Our results indicate that incorporating genetic information and family history in prostate cancer risk models can be particularly useful for identifying younger men that might benefit from PSA screening.</p></sec><sec id="S5"><title>Impact</title><p id="P5">Although adding genetic risk markers improves model performance, the clinical utility of these genetic risk models is limited.</p></sec></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Danemark</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Californie</li><li>Catalogne</li><li>Colorado</li><li>Grand Londres</li><li>Géorgie (États-Unis)</li><li>Hawaï</li><li>Hovedstaden</li><li>Lombardie</li><li>Maryland</li><li>Massachusetts</li><li>Missouri (État)</li><li>Oxfordshire</li><li>Rhône-Alpes</li><li>Utrecht (province)</li><li>Victoria (État)</li><li>État de New York</li></region><settlement><li>Barcelone</li><li>Copenhague</li><li>Londres</li><li>Los Angeles</li><li>Lyon</li><li>Melbourne</li><li>Milan</li><li>Oxford</li><li>Saint-Louis (Missouri)</li><li>Utrecht</li></settlement><orgName><li>Université d'Oxford</li><li>Université de Californie du Sud</li><li>Université de Melbourne</li><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name></region><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><name sortKey="Andriole, Gerald" sort="Andriole, Gerald" uniqKey="Andriole G" first="Gerald" last="Andriole">Gerald Andriole</name><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><name sortKey="Crawford, E David" sort="Crawford, E David" uniqKey="Crawford E" first="E. David" last="Crawford">E. David Crawford</name><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W. Ryan" last="Diver">W. Ryan Diver</name><name sortKey="Ganziano, J Michael" sort="Ganziano, J Michael" uniqKey="Ganziano J" first="J. Michael" last="Ganziano">J. Michael Ganziano</name><name sortKey="Ganziano, J Michael" sort="Ganziano, J Michael" uniqKey="Ganziano J" first="J. Michael" last="Ganziano">J. Michael Ganziano</name><name sortKey="Giovannucci, Edward" sort="Giovannucci, Edward" uniqKey="Giovannucci E" first="Edward" last="Giovannucci">Edward Giovannucci</name><name sortKey="Giovannucci, Edward" sort="Giovannucci, Edward" uniqKey="Giovannucci E" first="Edward" last="Giovannucci">Edward Giovannucci</name><name sortKey="Giovannucci, Edward" sort="Giovannucci, Edward" uniqKey="Giovannucci E" first="Edward" last="Giovannucci">Edward Giovannucci</name><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B." last="Hayes">Richard B. Hayes</name><name sortKey="Henderson, Brian" sort="Henderson, Brian" uniqKey="Henderson B" first="Brian" last="Henderson">Brian Henderson</name><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><name sortKey="Stampfer, Meir" sort="Stampfer, Meir" uniqKey="Stampfer M" first="Meir" last="Stampfer">Meir Stampfer</name><name sortKey="Stampfer, Meir" sort="Stampfer, Meir" uniqKey="Stampfer M" first="Meir" last="Stampfer">Meir Stampfer</name><name sortKey="Stampfer, Meir" sort="Stampfer, Meir" uniqKey="Stampfer M" first="Meir" last="Stampfer">Meir Stampfer</name><name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O." last="Stram">Daniel O. Stram</name><name sortKey="Thun, Michael J" sort="Thun, Michael J" uniqKey="Thun M" first="Michael J." last="Thun">Michael J. Thun</name><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name><name sortKey="Weinstein, Stephanie J" sort="Weinstein, Stephanie J" uniqKey="Weinstein S" first="Stephanie J." last="Weinstein">Stephanie J. Weinstein</name><name sortKey="Willett, Walter C" sort="Willett, Walter C" uniqKey="Willett W" first="Walter C." last="Willett">Walter C. Willett</name><name sortKey="Yeager, Meredith" sort="Yeager, Meredith" uniqKey="Yeager M" first="Meredith" last="Yeager">Meredith Yeager</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Cox, David" sort="Cox, David" uniqKey="Cox D" first="David" last="Cox">David Cox</name></region><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Cox, David" sort="Cox, David" uniqKey="Cox D" first="David" last="Cox">David Cox</name></region><name sortKey="Allen, Naomi E" sort="Allen, Naomi E" uniqKey="Allen N" first="Naomi E." last="Allen">Naomi E. Allen</name><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name></country><country name="Allemagne"><noRegion><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name></noRegion></country><country name="Pays-Bas"><noRegion><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H. Bas" last="Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name></noRegion><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H. Bas" last="Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name></region><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Gonzalez, Carlos A" sort="Gonzalez, Carlos A" uniqKey="Gonzalez C" first="Carlos A." last="Gonzalez">Carlos A. Gonzalez</name></region></country><country name="Suède"><noRegion><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name></noRegion></country><country name="Italie"><region name="Lombardie"><name sortKey="Pala, Valeria" sort="Pala, Valeria" uniqKey="Pala V" first="Valeria" last="Pala">Valeria Pala</name></region></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Tjonneland, Anne" sort="Tjonneland, Anne" uniqKey="Tjonneland A" first="Anne" last="Tjonneland">Anne Tjonneland</name></region></country><country name="Grèce"><noRegion><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name></noRegion></country><country name="Finlande"><noRegion><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Common genetic variants in prostate cancer risk prediction – Results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3)
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